PXB Mouse Services
Evaluation of a chimeric (uPA+/+)/SCID mouse model with a humanized liver for prediction of human metabolism.
PXB Mouse Services
De Serres M, Bowers G, Boyle G, Beaumont C, Castellino S, Sigafoos J, Dave M, Roberts A, Shah V, Olson K, Patel D, Wagner D, Yeager R, Serabjit-Singh C.
Xenobiotica. 2011 Jun;41(6):464-75.
ME3738 enhances the effect of interferon and inhibits hepatitis C virus replication both in vitro and in vivo.
PXB Mouse Services
Abe H, Imamura M, Hiraga N, Tsuge M, Mitsui F, Kawaoka T, Takahashi S, Ochi H, Maekawa T, Hayes CN, Tateno C, Yoshizato K, Murakami S, Yamashita N, Matsuhira T, Asai K, Chayama K.
J Hepatol. 2011 Jul;55(1):11-8. Epub 2010 Nov 29.
Growth hormone-dependent pathogenesis of human hepatic steatosis in a novel mouse model bearing a human hepatocyte-repopulated liver.
PXB Mouse Services
Tateno C, Kataoka M, Utoh R, Tachibana A, Itamoto T, Asahara T, Miya F, Tsunoda T, Yoshizato K.
Endocrinology. 2011 Apr;152(4):1479-91.
EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy.
PXB Mouse Services
Lupberger J, Zeisel MB, Xiao F, Thumann C, Fofana I, Zona L, Davis C, Mee CJ, Turek M, Gorke S, Royer C, Fischer B, Zahid MN, Lavillette D, Fresquet J, Cosset FL, Rothenberg SM, Pietschmann T, Patel AH, Pessaux P, Doffoël M, Raffelsberger W, Poch O, McKea
Nat Med. 2011 May;17(5):589-95.
Transmissibility of hepatitis B virus (HBV) infection through blood transfusion from blood donors with occult HBV infection.
PXB Mouse Services
Yuen MF, Wong DK, Lee CK, Tanaka Y, Allain JP, Fung J, Leung J, Lin CK, Sugiyama M, Sugauchi F, Mizokami M, Lai CL.
Clin Infect Dis. 2011 Mar;52(5):624-32
Cross-species transmission of gibbon and orangutan hepatitis B virus to uPA/SCID mice with human hepatocytes.
PXB Mouse Services
Sa-Nguanmoo P, Tanaka Y, Ratanakorn P, Sugiyama M, Murakami S, Payungporn S, Sommanustweechai A, Mizokami M, Poovorawan Y.
Virus Res. 2011 Jun;158(1-2):209-15
Elimination of hepatitis C virus by short term NS3-4A and NS5B inhibitor combination therapy in human hepatocyte chimeric mice.
PXB Mouse Services
Ohara E, Hiraga N, Imamura M, Iwao E, Kamiya N, Yamada I, Kono T, Onishi M, Hirata D, Mitsui F, Kawaoka T, Tsuge M, Takahashi S, Abe H, Hayes CN, Ochi H, Tateno C, Yoshizato K, Tanaka S, Chayama K.
J Hepatol. 2011 May;54(5):872-8
Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes.
PXB Mouse Services
Takano T, Tsukiyama-Kohara K, Hayashi M, Hirata Y, Satoh M, Tokunaga Y, Tateno C, Hayashi Y, Hishima T, Funata N, Sudo M, Kohara M.
In press
In vitro evaluation of cytochrome p450 and glucuronidation activities in hepatocytes isolated from liver-humanized mice.
PXB Mouse Services
Yamasaki C, Kataoka M, Kato Y, Kakuni M, Usuda S, Ohzone Y, Matsuda S, Adachi Y, Ninomiya S, Itamoto T, Asahara T, Yoshizato K, Tateno C.
Drug Metab Pharmacokinet. 2011 Jan 14;25(6):539-50
Animal model for study of human hepatitis viruses.
PXB Mouse Services
Chayama K, Hayes CN, Hiraga N, Abe H, Tsuge M, Imamura M.
J Gastroenterol Hepatol. 2011 Jan;26(1):13-8
Effect of hepatitis C virus infection on the mRNA expression of drug transporters and cytochrome p450 enzymes in chimeric mice with humanized liver.
PXB Mouse Services
Kikuchi R, McCown M, Olson P, Tateno C, Morikawa Y, Katoh Y, Bourdet DL, Monshouwer M, Fretland AJ.
Drug Metab Dispos. 2010 Nov;38(11):1954-61.
Activation of morphine glucuronidation by fatty acyl-CoAs and its plasticity: a comparative study in humans and rodents including chimeric mice carrying human liver.
PXB Mouse Services
Nurrochmad A, Ishii Y, Nakanoh H, Inoue T, Horie T, Sugihara K, Ohta S, Taketomi A, Maehara Y, Yamada H.
Drug Metab Pharmacokinet. 2010;25(3):262-73
Practical evaluation of a mouse with chimeric human liver model for hepatitis C virus infection using an NS3-4A protease inhibitor.
PXB Mouse Services
Kamiya N, Iwao E, Hiraga N, Tsuge M, Imamura M, Takahashi S, Miyoshi S, Tateno C, Yoshizato K, Chayama K.
J Gen Virol. 2010 Jul;91(Pt 7):1668-77. Epub 2010 Feb 17.
Hepatic Hyperplasia Associated with Discordant Xenogeneic Parenchymal-Nonparenchymal Interactions in Human Hepatocyte-Repopulated Mice.
PXB Mouse Services
Utoh R, Tateno C, Kataoka M, Tachibana A, Masumoto N, Yamasaki C, Shimada T, Itamoto T, Asahara T, Yoshizato K.
Am J Pathol. 2010 177 654-665
Activation of Morphine Glucuronidation by Fatty Acyl-CoAs and Its Plasticity: A Comparative Study in Humans and Rodents Including Chimeric Mice Carrying Human Liver.
PXB Mouse Services
Nurrochmad A, Ishii Y, Nakanoh H, Inoue T, Horie T, Sugihara K, Ohta S, Taketomi A, Maehara Y, Yamada H.
Drug Metab Pharmacokinet. in press.
Approach for in vivo protein binding of 5-n-butyl-pyrazolo[1,5-a]pyrimidine bioactivated in chimeric mice with humanized liver by two-dimensional electrophoresis with accelerator mass spectrometry.
PXB Mouse Services
Yamazaki H, Kuribayashi S, Inoue T, Tateno C, Nishikura Y, Oofusa K, Harada D, Naito S, Horie T, Ohta S.
Chem Res Toxicol. 2010 Jan;23(1):152-8.
Amphipathic DNA polymers inhibit hepatitis C virus infection by blocking viral entry.
PXB Mouse Services
Matsumura T, Hu Z, Kato T, Dreux M, Zhang YY, Imamura M, Hiraga N, Juteau JM, Cosset FL, Chayama K, Vaillant A, Liang TJ.
Gastroenterology. 2009 Aug;137(2):673-81
Absence of viral interference and different susceptibility to interferon between hepatitis B virus and hepatitis C virus in human hepatocyte chimeric mice.
PXB Mouse Services
Hiraga N, Imamura M, Hatakeyama T, Kitamura S, Mitsui F, Tanaka S, Tsuge M, Takahashi S, Abe H, Maekawa T, Ochi H, Tateno C, Yoshizato K, Wakita T, Chayama K.
J Hepatol. 2009 Dec;51(6):1046-54. Epub 2009 Sep 23.
Hepatocytes from fibrotic liver possess high growth potential in vivo
PXB Mouse Services
Nishie M, Tateno C, Utoh R, Kohashi T, Masumoto N, Kobayashi N, Itamoto T, Tanaka N, Asahara T, Yoshizato K.
Cell Transplant. 2009;18(5):665-75.
G-to-A Hypermutation in Hepatitis B Virus (HBV) and Clinical Course of Patients with Chronic HBV Infection.
PXB Mouse Services
Noguchi C, Imamura M, Tsuge M, Hiraga N, Mori N, Miki D, Kimura T, Takahashi S, Fujimoto Y, Ochi H, Abe H, Maekawa T, Tateno C, Yoshizato K, Chayama K.
J Infect Dis. 2009 Jun 1;199(11):1599-1607.
